6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one

Nā ʻano kemika

6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one he wai moakaka melemele ʻole a māmā hoʻi, hoʻoheheʻe ʻole ʻia i ka wai, hoʻoheheʻe ʻia i loko o CHCl₃, pono e hoʻopaʻahau ʻia ka mālama ʻana, hoʻokaʻawale ʻia mai nā mea hoʻomake oxidants, nā kemika ʻai, mai ke ahi a me ke kumu wela.

Nā noi

6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-onehe waena ia o Alectinib, kahi mea hoʻopaʻa anaplastic lymphoma kinase (ALK) koho nui a ikaika loa i hiki ke ālai i ka mutant gatekeeper kūpaʻa, kahi e hopena ai i ka emi ʻana o ka ulu ʻana o nā cell.

ʻAno kino

Wai ʻole kala a melemele

Ola papa

Wahi a ko mākou ʻike, hiki ke mālama ʻia ka huahana no 12 mau lā ma mua o ka lā.nā mahina mai ka lā i hāʻawi ʻia ai inā mālama ʻia i loko o nā pahu i hoʻopaʻa paʻa ʻia, pale ʻia mai ka mālamalama a me ka wela a mālama ʻia ma nā mahana ma waena o 5 -30°C.

Tnā waiwai maʻamau

Kikowaena paila

354.7±42.0 °C ma 760 mmHg

Kikowaena Uila

168.3±27.9 °C

Ka nuipa pololei

282.025543

PSA

26.30000

LogP

3.25

Kaomi mahu

0.0±0.8 mmHg ma 25°C

Papa Kuhikuhi o ka Refraction

1.545

pka

1.26±0.10 (Wānana ʻia)

Ka hoʻoheheʻe ʻana i ka wai

50 mg/ml i loko o CHCl₃