3 mau ala hoihoi i kūkulu ʻia e ka poʻe kemika i nā pūhui i kēia makahiki
na Bethany Halford
NA ENZYME KUKULU I KUKULU BIARYL BONDS
Papahana e hōʻike ana i kahi huila biaryl i hoʻopaʻa ʻia e ka enzyme.
Hoʻohana ka poʻe kemika i nā molekala biaryl, e pili ana i nā pūʻulu aryl i hoʻopaʻa ʻia kekahi i kekahi e ka paʻa hoʻokahi, e like me nā ligands chiral, nā mea kūkulu hale, a me nā lāʻau lapaʻau.Akā, ʻo ka hana ʻana i ka motif biaryl me nā hopena metala-catalyzed, e like me Suzuki a me Negishi cross-couplings, koi maʻamau i nā ʻanuʻu synthetic e hana i nā hoa pili.ʻO ka mea hou aʻe, ua haʻalulu kēia mau hopena metala-catalyzed i ka wā e hana ai i nā biaryls nui.Hoʻoulu ʻia e ka hiki ʻana o nā enzymes e hoʻokalakupua i nā hopena, ua hoʻohana kahi hui i alakaʻi ʻia e ke Kulanui o Michigan ʻo Alison RH Narayan i ka evolution e hana i kahi enzyme cytochrome P450 e kūkulu ana i kahi mole biaryl ma o ka hoʻohui ʻana o nā paʻa carbon-hydrogen aromatic.Hoʻopili ka enzyme i nā molekala ʻala e hana i hoʻokahi stereoisomer a puni kahi paʻa me ka hoʻohuli ʻana (hōʻike ʻia).Manaʻo ka poʻe noiʻi hiki i kēia ala biocatalytic ke lilo i hoʻololi berena a me ka pata no ka hana ʻana i nā paʻa biaryl (Nature 2022, DOI: 10.1038/s41586-021-04365-7).
PALAPALA NO NA AMINE TERTIA I PILI I KA PAAKAI LIILI
Hōʻike ka papahana i ka hopena e hana ai i nā amine tertiary mai nā mea kiʻekiʻe.
ʻO ka hui pū ʻana i nā mea hoʻoheheʻe metala pōloli me nā amine waiwai electron e pepehi maʻamau i nā catalysts, no laila ʻaʻole hiki ke hoʻohana ʻia nā mea hoʻohui metala e kūkulu i nā amine kiʻekiʻe mai nā amine lua.Ua ʻike ʻo M. Christina White a me nā hoa hana ma ke Kulanui o Illinois Urbana-Champaign hiki iā lākou ke hoʻoponopono i kēia pilikia inā hoʻohui lākou i kahi mea paʻakai i kā lākou meaʻai reactant.Ma ka hoʻololi ʻana i nā amine lua i mau paʻakai ammonium, ua ʻike ka poʻe chemist hiki iā lākou ke hana i kēia mau pūhui me nā olefins terminal, kahi mea ʻokiʻoki, a me kahi catalyst palladium sulfoxide e hana i nā amine tertiary lehulehu me nā hui hana like ʻole (e like me ka laʻana).Ua hoʻohana ka poʻe chemists i ka hopena e hana i nā lāʻau antipsychotic Abilify a me Semap a e hoʻololi i nā lāʻau i loaʻa i nā amine lua, e like me ka antidepressant Prozac, i mau amine tertiary, e hōʻike ana i ka hana ʻana o nā chemists i nā lāʻau hou mai nā mea i loaʻa (Science 2022, DOI: 10.1126/science.abn8382).
ALOHA ANA O AZARENES i ka aelike kalapona
Hōʻike ka papahana i kahi quinoline N-oxide i hoʻololi ʻia i N-acylindole.
I kēia makahiki ua hoʻohui ʻia nā chemists i ka repertoire o ka hoʻoponopono molekala, ʻo ia nā hopena e hoʻololi ai i nā cores o nā molekala paʻakikī.I kekahi laʻana, ua hoʻomohala ka poʻe noiʻi i kahi hoʻololi e hoʻohana ana i ka māmā a me ka waikawa e ʻoki i hoʻokahi kalapona mai loko mai o nā azaarenes ʻeono i loko o nā quinoline N-oxides e hana ai i nā N-acylindole me nā apo lima ʻelima (hōʻike ʻia).ʻO ka hopena, i hoʻomohala ʻia e ka poʻe chemists ma ka hui ʻo Mark D. Levin ma ke Kulanui o Chicago, ua hoʻokumu ʻia ma ka hopena e pili ana i kahi kukui mercury, e hoʻopau ana i nā lōʻihi hawewe he nui.Ua ʻike ʻo Levin a me nā hoa hana ʻo ka hoʻohana ʻana i kahi diode kukui e hoʻopuka ana i ka mālamalama ma 390 nm i hāʻawi iā lākou i ka mana maikaʻi aʻe a ʻae iā lākou e hana i ka hopena maʻamau no nā quinoline N-oxides.Hāʻawi ka hopena hou i nā mea hana mole i ke ala e hoʻoponopono hou ai i nā kiko o nā pūhui paʻakikī a hiki ke kōkua i nā lāʻau lapaʻau e nānā ana e hoʻonui i kā lākou hale waihona puke o nā moho lāʻau (Science 2022, DOI: 10.1126/science.abo4282).
Ka manawa hoʻouna: Dec-19-2022