3 mau ala hoihoi i kūkulu ai nā kemika i nā hui i kēia makahiki
na Bethany Halford
Nā ʻenzymes i hoʻomohala ʻia i kūkulu ʻia nā pilina BIARYL
ʻAno hoʻolālā e hōʻike ana i kahi hui biaryl i hoʻoulu ʻia e ka enzyme.
Hoʻohana nā Chemists i nā molekala biaryl, nona nā hui aryl i hoʻopaʻa ʻia kekahi i kekahi e kahi pilina hoʻokahi, e like me nā ligands chiral, nā mea kūkulu hale, a me nā lāʻau lapaʻau. Akā ʻo ka hana ʻana i ka motif biaryl me nā hopena catalyzed metal, e like me Suzuki lāua ʻo Negishi cross-couplings, pono pinepine i kekahi mau ʻanuʻu synthetic e hana i nā hoa hoʻopili. Eia kekahi, hāʻule kēia mau hopena catalyzed metal i ka wā e hana ai i nā biaryls bulky. Hoʻoulu ʻia e ka hiki o nā enzymes ke catalyze i nā hopena, ua hoʻohana kahi hui i alakaʻi ʻia e Alison RH Narayan o ke Kulanui o Michigan i ka evolution i kuhikuhi ʻia e hana i kahi enzyme cytochrome P450 e kūkulu ana i kahi molekala biaryl ma o ka hoʻopili oxidative o nā pilina carbon-hydrogen aromatic. Hoʻohui ka enzyme i nā molekala aromatic e hana i hoʻokahi stereoisomer a puni kahi pilina me ka rotation hindered (hōʻike ʻia). Manaʻo nā mea noiʻi hiki i kēia ʻano biocatalytic ke lilo i hoʻololi berena-a-pata no ka hana ʻana i nā pilina biaryl (Nature 2022, DOI: 10.1038/s41586-021-04365-7).
ʻO ka meaʻai no nā ʻAmine Tertiary i hilinaʻi ʻia ma kahi paʻakai liʻiliʻi
Hōʻike ke kiʻi i kahi hopena e hana ai i nā amine tertiary mai nā amine lua.
ʻO ka hoʻohuihui ʻana i nā mea hoʻoulu metala makemake nui i ka electron me nā amines waiwai i ka electron e pepehi pinepine i nā mea hoʻoulu, no laila ʻaʻole hiki ke hoʻohana ʻia nā mea hoʻoulu metala e kūkulu i nā amines tertiary mai nā amines lua. Ua ʻike ʻo M. Christina White a me nā hoa hana ma ke Kulanui o Illinois Urbana-Champaign hiki iā lākou ke hoʻoponopono i kēia pilikia inā hoʻohui lākou i kahi mea ʻala paʻakai i kā lākou mea hana reactant. Ma ka hoʻololi ʻana i nā amines lua i nā paʻakai ammonium, ua ʻike nā kemika hiki iā lākou ke hana i kēia mau hui me nā olefins terminal, kahi oxidant, a me kahi mea hoʻoulu palladium sulfoxide e hana i nā amines tertiary he nui me nā ʻano hui hana like ʻole (hōʻike ʻia ka laʻana). Ua hoʻohana nā kemika i ka hopena e hana i nā lāʻau antipsychotic ʻo Abilify lāua ʻo Semap a e hoʻololi i nā lāʻau lapaʻau e kū nei he mau amines lua, e like me ka antidepressant Prozac, i nā amines tertiary, e hōʻike ana pehea e hana ai nā kemika i nā lāʻau lapaʻau hou mai nā mea e kū nei (Science 2022, DOI: 10.1126/science.abn8382).
Ua emi ke kalapona o nā AZAARENES
Hōʻike ke kiʻi i kahi quinoline N-oxide i hoʻololi ʻia i N-acylindole.
I kēia makahiki, ua hoʻohui nā kemika i ka papa inoa o ka hoʻoponopono molekala, ʻo ia hoʻi nā hopena e hoʻololi i nā ʻiʻo o nā molekala paʻakikī. Ma kekahi laʻana, ua hoʻomohala nā mea noiʻi i kahi hoʻololi e hoʻohana ana i ka mālamalama a me ka waikawa e ʻoki i hoʻokahi kalapona mai loko mai o nā azaarenes ʻeono-lālā i loko o nā quinoline N-oxides e hana i nā N-acylindoles me nā apo ʻelima-lālā (hōʻike ʻia ka laʻana). ʻO ka hopena, i hoʻomohala ʻia e nā kemika ma ka hui ʻo Mark D. Levin ma ke Kulanui o Chicago, ua hoʻokumu ʻia ma kahi hopena e pili ana i kahi kukui mercury, kahi e hoʻopuka ai i nā nalu he nui o ke kukui. Ua ʻike ʻo Levin a me nā hoa hana ʻo ka hoʻohana ʻana i kahi diode hoʻomālamalama e hoʻopuka ana i ka mālamalama ma 390 nm i hāʻawi iā lākou i ka mana maikaʻi aʻe a ʻae iā lākou e hana i ka hopena maʻamau no nā quinoline N-oxides. Hāʻawi ka hopena hou i nā mea hana molekala i kahi ala e hana hou ai i nā ʻiʻo o nā hui paʻakikī a hiki ke kōkua i nā kemika lāʻau lapaʻau e ʻimi nei e hoʻonui i kā lākou waihona puke o nā moho lāʻau lapaʻau (Science 2022, DOI: 10.1126/science.abo4282).
Ka manawa hoʻouna: Dec-19-2022